Emergent collective organization of bone cells in complex curvature fields

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    Received Check for updates Sebastien J. P. Callens 1,2, Daniel Fan 3, Ingmar A. J. van Hengel1, Michelle Minneboo1, Pedro J. Díaz-Payno 1,4, Molly M. Stevens2, Lidy E. Fratila-Apachitei1 and amp; Amir A. Zadpoor 1 Individual cells and multicellular systems respond to cell-scale curvatures in their environments, guiding migration, orientation, and tissue formation. The authors quantify curvature-induced patterning and find that cells generally prefer regions with at least one negative principal curvature. In recent years, numerous studies have begun to address the role of cell-scale curvature . . .

     

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