HIGHLIGHTS
- who: ADPKD (autosomal dominant polycystic and collaborators from the University of Bari Aldo Moro, Italy have published the research: Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling, in the Journal: (JOURNAL)
- what: This study demonstrated that the greatest amount of variation occurs in fragments within CpG islands and gene bodies, but not within intergenic fragments across the ADPKD kidney. This work provided evidence that different DNA methylation changes contributes to the development of each cyst. cAMP signaling has been reported to induce cardiac hypertrophy through regulating DNA methylation (Fang . . .
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