HIGHLIGHTS
SUMMARY
The unsatisfying clinical therapeutic effect may have been due to several reasons such as strong invasiveness, easy relapse owing to the self-renewal and multi-lineage differentiation properties of glioma stem_cells (GSCs), low drug delivery potency restricted by the bloodbrain barrier (BBB), as well as the "immune privileged" state of the brain. Whether it is from the perspective of outputs or quality, there is no doubt that the United_States has played the most important role in the field of OVT-CNSTs research in the past decades. Of note, multiple previous bibliometric studies have also . . .
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