HIGHLIGHTS
- who: Karina Ervik from the Department of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, POBox, Blindern, Oslo, Norway have published the research work: Enantioselective Trost alkynylation with 2E,4E-5-bromo-2,4-pentadienal, in the Journal: (JOURNAL) of 23/03/2022
SUMMARY
A slight excess of TMS-acetylene (2a) and Me2Zn was used, while aldehyde 1 was added as a solid in one portion.[13] Triphenylphosphine oxide (TPPO, 20 mol%) may improve both the enantioselectivity and yields.[14] The same conditions returned 4a in 42% isolated yield and an enantiomeric excess . . .
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