Encoding and decoding of p53 dynamics in cellular response to stresses

HIGHLIGHTS

  • who: Ping Wang and collaborators from the Kuang Yaming Honors School, Nanjing University, Nanjing, China have published the paper: Encoding and Decoding of p53 Dynamics in Cellular Response to Stresses, in the Journal: Cells 2023, 12, 490. of /2023/
  • what: In this review the authors focused on how stresses are encoded into p53 dynamics and how the dynamics are decoded into cellular outcomes. A Boolean model is developed to investigate cell-fate decisions contemplating three possible phenotypes: autophagy, apoptosis, and senescence . The authors focus on Mdm2/MdmX as the primary regulators of p53 activity and . . .

     

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