HIGHLIGHTS
- who: Nathan Eaton from the Bio-Medico University, Italy have published the research work: Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice, in the Journal: (JOURNAL)
- how: Together the data showed that Mpl-mediated endocytosis in platelets and MKs required DNM2 expression to regulate plasma TPO levels. The data showed that the severe anemia of Mpl-/- Dnm2Plt-/- mice was due to a blockade of erythroid maturation at an early CD71high stage.
SUMMARY
Dnm2Plt-/- mice were crossed with Mpl-/- mice to obtain mice lacking DNM2 in platelets . . .
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