Endogenous glutamine is rate-limiting for anti-cd3 and anti-cd28 induced cd4 t-cell proliferation and glycolytic activity under hypoxia and normoxia

HIGHLIGHTS

• who: Jonas A. Wik et al. from the DivisionUniversity of have published the research: Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4 T-cell proliferation and glycolytic activity under hypoxia and normoxia, in the Journal: (JOURNAL) of 13/06/2022

SUMMARY

Antigen recognition and co-stimulation of CD4+ T_cells to proliferation, differentiation and clonal expansion in_vivo are metabolically challenging processes as availability of key nutrients may vary. To meet the demand for energy and biomass, activated CD4+ T_cells are fully dependent on rapid uptake and consumption of glucose . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or Email

Password

Remember me

Lost your password?

If you don't have an account, you can create one here.