Endogenous glutamine is rate-limiting for anti-cd3 and anti-cd28 induced cd4 t-cell proliferation and glycolytic activity under hypoxia and normoxia

HIGHLIGHTS

• who: Oslo and collaborators from the DivisionUniversity of have published the research work: Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4 T-cell proliferation and glycolytic activity under hypoxia and normoxia, in the Journal: (JOURNAL) of 13/06/2022

SUMMARY

Antigen recognition and co-stimulation of CD4+ T_cells to proliferation, differentiation and clonal expansion in_vivo are metabolically challenging processes as availability of key nutrients may vary. To meet the demand for energy and biomass, activated CD4+ T_cells are fully dependent on rapid uptake and consumption of glucose (Gluc . . .

 



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