Endogenous production of hyaluronan, prg4, and cytokines is sensitive to cyclic loading in synoviocytes

HIGHLIGHTS

• who: Meghana Pendyala et al. from the New York, United States of, Department of Biomedical Engineering, University of Connecticut have published the research work: Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes, in the Journal: PLOS ONE of 11/04/2022
• what: This study shows that cyclic loading can be used tool to modulate the endogenous production of hyaluronan PRG4 and cytokines from synovial fibroblasts. The authors show that 5% strain seems to decrease the concentration of cytokines and chemokines that are typically elevated in pathological joints, while higher . . .
  

   

  

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