Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues

HIGHLIGHTS

• who: Courtney W. Hanna from the Babraham Institute, Cambridge, UK have published the research: Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues, in the Journal: (JOURNAL)
• what: The authors show that oocyte-derived H3K27me3 associated with non-canonical imprints is not maintained beyond pre-implantation development at these elements and is replaced by secondary imprinted DNA methylation on the maternal allele in post-implantation ExE while being completely silenced by bi-allelic DNA methylation in the epiblast. Using publicly available bisulphite and RNA sequencing data from C57BL/6 germ cells and early . . .
  

   

  

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