HIGHLIGHTS
- who: Manu Rangachari from the University of Hasselt, Belgium (INSERM), France have published the research work: Endogenous T Cell Receptor Rearrangement Represses Aggressive Central Nervous System Autoimmunity in a TcR-Transgenic Model on the Non-Obese Diabetic Background, in the Journal: (JOURNAL)
- how: Together the data showed that allelic inclusion of endogenously rearranged TcR is both widespread and essential for proper development of the T_cell repertoire in 1C6 mice.
SUMMARY
The authors found that naïve 1C6 × Rag1-/- mice have diminished numbers of both CD4+ and CD8+ T_cells. This severe effect . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.