HIGHLIGHTS
- who: TRAIL-R and colleagues from the University of California, Irvine, United States have published the paper: Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells, in the Journal: (JOURNAL)
- what: The authors aimed to elucidate the significance of the endogenous levels of TRAIL-R4 for TRAIL-induced signaling pathways in cancer cells. The authors show that knockdown of TRAIL-R4 increased ERK-activity in MDA-MB-231 cells as well, leading to the upregulation of Bcl-xL and decreased sensitivity of these cells to treatment with recombinant TRAIL . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.