HIGHLIGHTS
- who: from the Department of Gastrenterology-Hepatology, Leiden University Medical Center, RC Leiden have published the Article: Endoglin: Beyond the Endothelium Mark J, in the Journal: (JOURNAL)
- what: This work has been extended, with multiple studies showing an important role for endoglin in tumor angiogenesis and strategies for inhibiting tumor angiogenesis by targeting endoglin. Interestingly, all the studies described above indicate that endoglin is involved in the polarization of macrophages. This study showed that endoglin is expressed by activated CD4+ T-cells and that endoglin is able to counteract the suppressive signal induced by TGF . . .
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