HIGHLIGHTS
- who: Tessa Gerrits et al. from the Department of Pathology, Leiden University Medical Centre, ZA Leiden, The Netherlands have published the article: Endoglin Is an Important Mediator in the Final Common Pathway of Chronic Kidney Disease to End-Stage Renal Disease, in the Journal: (JOURNAL) of 30/Nov/2022
- what: The authors show that endoglin, the co-receptor of the Tu03b2R is upregulated in the human interstitium in CKD. The authors show that overexpression of endoglin in kidney fibroblast increases the TGF-u03b2-mediated upregulation of pro-fibrotic downstream targets of TGF-u03b2, resulting in . . .
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