HIGHLIGHTS
- who: December and collaborators from the Nara Institute of Science and Technology (NAIST), Japan Medical University, China have published the paper: Endometrial small extracellular vesicles regulate human trophectodermal cell invasion by reprogramming the phosphoproteome landscape, in the Journal: (JOURNAL)
- what: In the current study, using mass spectrometry-based proteomics and phosphoproteomics, the authors demonstrate that EP-regulated endometrial cell-derived sEVs (but not E-regulated sEVs) promote hTSCs invasion via MAPK activation and that pharmacological inhibition of MAPK activation abrogates this process.
SUMMARY
Dysregulation of EV-mediated signalling from placental tissue . . .
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