Endothelial cell-derived mmp19 promotes pulmonary fibrosis by inducing e(nd)mt and monocyte infiltration

HIGHLIGHTS

• who: Weiming Zhao from the were narcotized by inhaling, % isoflurane (RWD, Shenzhen, China) (diluted with, Propanediol (Aladdin, Shanghai, China)), and then were given , u00b5L MMP WT-AAV or MMP E, AAV (, u00d7 u00ad, Vu00b7g/ mL) (HANBIO, Shanghai, China) by intratracheal injectionBecause recombinant adeno-associated viruses (rAAV) are promising gene transfer vectors that produce long-term expression without toxicity [15], therefore, the overexpression of , in mice lungs were achieved after AAV injection. On day, MMP WT-AAV and MMP E, AAV-infected mice were selected randomly and narcotized as before and intratracheal injected with , u00b5L PBS or BLM . . .
  

   

  

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