HIGHLIGHTS
- who: Simon Lambden from the Department of Physiology, and Neuroscience, UK have published the research work: Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors, in the Journal: (JOURNAL)
- what: The authors demonstrate differences between HIF deficient animals and controls in in_vivo and ex vivo vascular and metabolic status in baseline, hypoxic and inflammatory states that suggest a role for the HIF isoforms in regulating vascular endothelial function.
- how: The authors developed a series of transgenic mouse models the HIF-1α Tie2Cre deficient in HIF1-α in the systemic . . .
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