Endothelial cells activated by extracellular histones promote foxp3+ suppressive treg cells in vitro

HIGHLIGHTS

• who: Marine Arnaud and collaborators from the Human Immunology, Pathophysiology and Immunotherapy, INSERM U, University Paris Cite, Paris, France have published the article: Endothelial Cells Activated by Extracellular Histones Promote Foxp3+ Suppressive Treg Cells In Vitro, in the Journal: (JOURNAL) of 20/04/2022
• what: The authors showed that endothelial cells activated by extracellular histones induced the expansion of a specific FoxP3hi Treg subpopulation in co-culture experiments. Previous studies in this model have shown that, under inflammatory conditions, human microvascular endothelial cells can induce proliferation of CD4+ -T lymphocytes and selectively expand pro-inflammatory . . .
  

   

  

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