Endothelial deletion normalizes notch4-induced brain arteriovenous malformation in mice

HIGHLIGHTS

• who: BRIEF DEFINITIVE REPORT and collaborators from the for Accelerated Vascular Research, Department of Surgery, University of California, San Francisco, San Francisco, CA have published the Article: Endothelial deletion normalizes Notch4-induced brain arteriovenous malformation in mice, in the Journal: (JOURNAL) of 06/Dec/2022
• what: While this study provides a novel strategy by which targeting Notch signaling can normalize AVM pathologies, targeting Rbpj itself is not ideal as it affected animal health at a later stage.
• how: Virtually no relapse after complete AVM regression despite re-expression of Notch4*tetEC in adult . . .
  

   

  

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