HIGHLIGHTS
- who: Rui Li from the (UNIVERSITY) have published the article: Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2, in the Journal: (JOURNAL) of 27/03/2023
- what: The authors report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ which limits the activity of these transcriptional cofactors during developmental and tumor angiogenesis by promoting their degradation. The authors show that loss of endothelial FAT1 results in increased endothelial cell proliferation in_vitro and in various angiogenesis models in_vivo.
- how: Animal numbers used for . . .
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