Endothelial heparan sulfate 6-o-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor*

HIGHLIGHTS

• who: Cristina Ferreras from the (UNIVERSITY) have published the Article: Endothelial Heparan Sulfate 6-O-Sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor*, in the Journal: (JOURNAL) of October/19,/2012
• what: The authors investigated HS in tumors from patients with advanced stage ovarian cancer and demonstrated that 6S-containing motifs were overrepresented in ovarian tumor endothelium when compared with normal ovarian blood vessels.
• how: Binding of FGF2 to HS and to Endothelial Cell Surface Is Not Affected by Reduced 6-O-Sulfation . . .
  

   

  

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