Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model

HIGHLIGHTS

• who: Rebecca B. Riddle from the DepartmentUniversity of have published the research: Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model, in the Journal: Scientific Reports Scientific Reports
• what: The authors used this platform to explore the effects of different ECM composition on trans endothelial neutrophil migration. This work shows the importance of considering choice of ECM when designing organ-on-a-chip models. The use of human neutrophils increases the translational potential of this model, compared to use of immortalised cell lines. fMLP was added . . .
  

   

  

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