Endothelial protein kinase d1 is a major regulator of post-traumatic hyperinflammation

HIGHLIGHTS

• who: Jonathan Schu00f6nfelder from the University Medical Center Regensburg, Germany have published the Article: Endothelial Protein kinase D1 is a major regulator of post-traumatic hyperinflammation, in the Journal: (JOURNAL)
• what: The authors show a significant reduction in LTB 4 biosynthesis from PMNs upon LTA 4 H knockdown in HUVECs . The authors demonstrate an important role for intercellular communication by endothelial derived sEVs in propagating inflammatory signals after traumatic injury to the larger endothelium , but also to PMNs, summarized in Figure 11.
• how: A similar observation was made by shRNA mediated knockdown of . . .
  

   

  

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