Energy-stress-mediated ampk activation promotes gpx4- dependent ferroptosis through the jak2/stat3/p53 axis in renal cancer

HIGHLIGHTS

  • who: Renal Cancer and collaborators from the Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China have published the Article: Energy-Stress-Mediated AMPK Activation Promotes GPX4- Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer, in the Journal: Oxidative Medicine and Cellular Longevity of 15/08/2022
  • what: Considering that the underlying mechanisms of energy stress-mediated ferroptosis in cancer remain ambiguous, the authors explore the effects of energy stress on ferroptosis in renal cancer. The authors investigated whether P53 was involved in AMPKmediated GPX4-dependent ferroptosis.
  • how . . .

     

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