Engineered cord blood megakaryocytes evade killing by allogeneic t-cells for refractory thrombocytopenia

HIGHLIGHTS

  • who: Bijender Kumar et al. from the des Cordeliers (CRC), France Vanderbilt University, United States have published the article: Engineered cord blood megakaryocytes evade killing by allogeneic T-cells for refractory thrombocytopenia, in the Journal: (JOURNAL)
  • what: This study provides a proof-of-concept for a multifaceted approach to optimize CB-MKs as a consistently available source of off-the-shelf platelets that may be beneficial for alleviating the constraints on the platelet inventory.
  • how: Short durations of KD045 treatment also induced dose-dependent reductions in pMYPT1(Thr696) (p=0.0013 p=0 . . .

     

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