Engineered dna-encoded monoclonal antibodies targeting plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

HIGHLIGHTS

• who: Nicholas J. Tursi from the Philadelphia, PA, USAUniversity of have published the Article: Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model, in the Journal: Scientific Reports Scientific Reports
• future: Based on these preclinical data future studies to address safety and potency of the DMAb platform in humans may be of importance.

SUMMARY

A dual plasmid approach where heavy and light chains are encoded onto separate plasmids was used to further improve in_vivo expression as the authors have recently . . .

 



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