HIGHLIGHTS
SUMMARY
Optical manipulation is only possible up to a limited tissue depth, precluding the use of opto-based tools in non-light permeable tissues (Leopold et_al, 2018; Fleming et_al, 2019; Karginov et_al, 2014). Rok acts in synergy with myosin lightchain kinase (MLCK) to activate Spaghetti squash (Sqh/Myosin II regulatory light chain) with a sequential phosphorylation on Ser21 and Thr20, which in turn activates myosin II (Mizuno et_al, 1999; Winter et_al, 2001; Verdier et_al, 2006; Fig 1 b). The other known substrates of Rok are Myosin-binding subunit, Diaphanous/Diaphanous-related Formin, α-Adducin, LIM-kinase . . .
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