Engineered strail-armed mscs overcome sting deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade

HIGHLIGHTS

• who: Kevin Chih-Yang Huang from the Combined MSC and radiotherapy in an animal model BALB/c mice (female, weeks old) were maintained according to the institutional guidelines approved by the China Medical University Institutional Animal Care and Use Committee [Protocol NoCMUIACUC2018-167]. Before tumor cell inoculation, mice were randomized into different groups (five in each group). Briefly, CT26shSTING cells (, u00d7 , cells/ mouse) were suspended in , u03bcL of, % Matrigel and inoculated subcutaneously into the right flank of each mouse. After , days, the mice were intraperitoneally injected with , u00d7 , MSCs at, day intervals between injections. Irradiation (, Gy) was . . .
  

   

  

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