HIGHLIGHTS
- who: Emily J. Kay from the (UNIVERSITY) have published the research work: Engineering a suite of E. coli strains for enhanced expression of bacterial polysaccharides and glycoconjugate vaccines, in the Journal: (JOURNAL)
- what: The authors use recombinant S. pneumoniae serotype 4 capsule expression and glycan transfer as a model system to develop a bank of rationally designed E. coli strains for glycoconjugate vaccine production, using CRISPR recombination. This study showed a significant reduction in TLR4 activation by the Raptor strain, where lpxM has been removed using CRISPR mutagenesis, compared to the background strain W3110. This . . .
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