Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation*

HIGHLIGHTS

  • who: Jan Balzarini from the (UNIVERSITY) have published the research work: Engineering of a Single Conserved Amino Acid Residue of Herpes Simplex Virus Type 1 Thymidine Kinase Allows a Predominant Shift from Pyrimidine to Purine Nucleoside Phosphorylation*, in the Journal: (JOURNAL) of July/14,/2006

SUMMARY

    VOLUME 281. NUMBER 28 This is an Open Access article under the CC BY license. In contrast with its cytosolic TK-1 counterpart, HSV-1 TK can also recognize a variety of dUrd analogues with modifications in the base moiety (i.e. 5-substituted dUrd derivatives such . . .

     

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