Engineering of an anti-inflammatory peptide based on the disulfide-rich linaclotide scaffold

HIGHLIGHTS

• who: Claudia Cobos et al. from the Centre for Biodiscovery and Molecular Development of Therapeutics, AITHM, James Cook University have published the Article: Engineering of an Anti-Inflammatory Peptide Based on the Disulfide-Rich Linaclotide Scaffold, in the Journal: (JOURNAL)
• what: The authors show for the first time that the highly disulfide-rich peptide, linaclotide, can be used as a scaffold to confer anti-inflammatory activity in a TNBS mouse model of colitis. Despite the incomplete assignments, the NMR analysis indicates that the synthetic forms of MC12-linaclotide and linaclotide used in this study have . . .
  

   

  

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