HIGHLIGHTS
SUMMARY
Chondral defects in the transplantation group were filled with transparent tissue at 4 weeks (Fig 1c) which later turned white as articular cartilage, making it difficult to distinguish the area where cyiPS-Cart were transplanted from the surrounding articular cartilage area at 17 weeks after transplantation (Fig 1c). In contrast, there was no cell accumulation around chondral defects transplanted with allogeneic cyiPS-Cart (Fig 2a, b). cyiPS-Cart survived and directly contributed to hyaline cartilage-rich repaired tissue in chondral defects Single cells were prepared from undifferentiated cyiPSCs (cyiPSC), cyiPS-Cart (pre-transplant cyiPS . . .
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