HIGHLIGHTS
- What: The authors evaluated the feasibility of intraperitoneal administration of non-virally engineered MSCs to co-deliver CDUPRT/5-Flucytosine prodrug system and IFNb to potentially enhance the cGAS-STING signalling axis. While this study focuses on exploring the use of MSCs to deliver 5FU and IFNb, it is interesting to note that a preliminary study using the monocytic cell line THP1 showed that IFNb overexpression led to an enhancement in immune cell polarization (Additional file: 9).
- Who: Yoon Khei Ho from the kindly provided by Johnny Ong Chin-Ann, National Cancer Centre Singapore) in . . .
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