HIGHLIGHTS
- who: Sarah Nicol Lauder et al. from the Department of Medicine, Cardiff, UK have published the Article: Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3, in the Journal: (JOURNAL)
- what: In an extension of this work, the authors have examined the impact of PI-3065 on Treg and intratumoral effector T_cells identifying within Lauder SN, et_al J Immunother Cancer 2020;8:e000693. doi:10.1136/jitc-2020-000693 the latter population, increased proliferation of antigen- specific T_cells, enhanced self-renewal capacity, metabolic fitness and resistance to exhaustion as key consequences of successful PI3K . . .
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