Enhanced channel activity by pi(4,5)p2 ignites mlkl-related pathogenic processes

HIGHLIGHTS

• who: Bingqing Xia from the (UNIVERSITY) have published the paper: Enhanced channel activity by PI(4,5)P2 ignites MLKL-related pathogenic processes, in the Journal: (JOURNAL)
• what: The authors show that MLKL channel activity is finetuned by PI(4,5)P2 in a dose-dependent manner for the first time (Fig 1c-g).
• how: Since elevated PI(45)P2 level is a key factor for the MLKL-related inflammation the authors used PIP5K-knockdown BV2 cells to detect cytokine secretion level (Supplementary Fig S9g). The result showed that blocking the PI(45 . . .
  

   

  

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