Enhanced neutralization potency of an identical hiv neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

HIGHLIGHTS

• who: Thandeka Moyo-Gwete from the CentreUniversity of for the AIDS Programme of Research in South Africa have published the article: Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms, in the Journal: Scientific Reports Scientific Reports
• what: The authors show that the neutralization potency of the CAP88-CH06 IgG3 isotype is mediated by its long hinge region while the increased neutralization capacity of the IgA1 mAb is modulated by the CH1 region of the antibody.
• how: Using an CAP88 autologous virus from . . .
  

   

  

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