HIGHLIGHTS
SUMMARY
Interestingly, BMS often coexists with other syndromes referred to as central sensitivity syndromes such as temporo-mandibular disorder (TMD), fibromyalgia or visceral pain. BMS might thus share common mechanisms with these chronic pain syndromes, including abnormal endogenous pain modulation. One of the major endogenous pain inhibitory systems is conditioned pain modulation (CPM; formerly diffuse noxious inhibitory controls), a powerful general endogenous analgesic mechanism which can completely inhibit incoming nociceptor signals at the primary synapse. CPM is believed to play an important role in the development and exacerbation of chronic pain, because dysfunction of CPM . . .
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