Enhancement of vitamin b6 production driven by omics analysis combined with fermentation optimization

HIGHLIGHTS

• What: The authors conducted transcriptome and metabolome analyses to investigate the effects of the accumulation of pyridoxine which is the major commercial form of vitamin B6 on cellular processes in Escherichia coli. In this study, gene_expression at different fermentation periods (6 h, 9 h, and 24 h) was analyzed, and the key genes involved in the production of γ-PGA and nattokinase were identified. The authors aimed to better understand the implications of artificially altering the metabolic pathways of the strains by transcriptomic profiling and metabolomics. In this study, transcriptome samples were obtained from the LL388 strain in . . .
  

   

  

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