Enhancement through mutagenesis of the binding of the isolated kringle 2 domain of human plasminogen to ã?‰-amino acid ligands and to an internal sequence of a streptococcal surface protein*

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  • who: Stephanie L. Nilsen from the (UNIVERSITY) have published the Article: Enhancement through Mutagenesis of the Binding of the Isolated Kringle 2 Domain of Human Plasminogen to Ã?‰-Amino Acid Ligands and to an Internal Sequence of a Streptococcal Surface Protein*, in the Journal: (JOURNAL) of March/10,/1999
  • what: The results of this study have shown that strategic rational and knowledge-based minimal mutagenesis of K2Pg can be employed to up-regulate its LBS, which then can be employed to engineer enhanced functionality into this kringle domain, and likely then into the parent molecule, hPg . . .

     

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