Enhancing survival of mouse oocytes following chemotherapy or aging by targeting bax and rad51

HIGHLIGHTS

  • who: Loro L. Kujjo et al. from the Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America, Program of Developmental and Reproductive Biology have published the Article: Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51, in the Journal: (JOURNAL) of February/12,/2010
  • what: The authors show that DXR induced both single- and doublestrand DNA breaks in oocytes of B6C3F1 mice . The authors show that chemoresistance in oocytes is dependent on Rad51 due to its central role in homologous DNA repair of DXR-induced DDSBs . . .

     

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