HIGHLIGHTS
- What: As examples of fibroblast-derived ECM proteins the authors examine Collagen Triple Helix Repeat Containing 1 (CTHRC1) and Transforming Growth Factor-β-inducible protein (TGFBI) also known as This study demonstrated that wound bed myofibroblasts upregulated Acta2 and Col1a1 mRNA expression compared to fibroblast populations from uninjured skin . The authors propose that identifying co-factors to TGF-β-driven myofibroblast activation and pro-fibrotic ECM deposition may represent potential targets for therapeutic development.
- Who: Immunology and collaborators from the Mateusz, University of Illinois Chicago, Chicago, USA have published the article: Enter the Matrix: Fibroblast-immune cell . . .
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