HIGHLIGHTS
- who: Emily W. Helm from the University of Antofagasta, Chile University of Delaware, United States have published the research work: Environmentally-triggered contraction of the norovirus virion determines diarrheagenic potential, in the Journal: (JOURNAL)
- what: The authors report that the protruding (P) domain of the major norovirus capsid protein VP1 is a key virulence determinant. The authors used a recently developed small animal model of acute, self-resolving norovirus diarrhea to demonstrate that intestinal disease is regulated by the responsiveness of the viral capsid to environmental cues that trigger contraction of the VP1 A B . . .
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