HIGHLIGHTS
SUMMARY
It prompted the detailed analytical characterization of mAb1 free thiols to identify process step(s) responsible for the free thiol content variability, and mechanism(s) involved in free thiol formation, with the overall goal of improving process control over the total free thiol level content. Analytical characterization of mAb1 free thiols Free thiol analysis by RP-HPLC of mAb1 DS materials with varying total free thiol content indicated that the increased total free thiol content was predominantly due to the increased presence of mAb1 species containing 2 unpaired cysteine residues i.e., an equivalent . . .
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