HIGHLIGHTS
- who: Naoki Itokawa from the Graduate School Chiba University, Kyoto, Japan have published the article: Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: To further characterize the association between transcription factors and DARs, the authors focused on ATF and STAT binding motifs that showed a markedly high enrichment in aged HSC open DARs.
- how: To understand this discrepancy the authors evaluated chromatin accessibility around DEGs and found that the chromatin around DEGs was open and showed subtle changes between young and aged . . .
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