HIGHLIGHTS
SUMMARY
As outlined above, long-term nuclear maintenance and stable transgene_expression in therapeutically relevant cell types and tissues is a major challenge in nonviral_vector development. In this review, the authors will discuss recent progress in nonviral_vector development regarding (I) transgene_expression, (II) mitotic stability, and_(III) nuclear localization. The choice of the transgene promoter type has the most fundamental impact on transgene_expression levels. The cytomegalovirus (CMV) early enhancer/promoter facilitates a high level of transgene_expression in various cell types. Linking the CMV promoter with an intron, 6 of 22 placed between promoter and transgene, was shown . . .
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