Epithelial-mesenchymal transition and metastasis under the control of transforming growth factor

HIGHLIGHTS

  • who: Yutaro Tsubakihara and Aristidis Moustakas from the Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, University have published the Article: Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor, in the Journal: (JOURNAL)
  • what: Unexpectedly, this study proposed that "weak" TGFβ signaling is required for the generation of tumor spheroids via budding and for the infiltrative dissemination of these tumors .
  • future: Future experiments may combine fate mapping of tumors in mouse models with non-invasive microscopy coupled to single-cell gene_expression analysis to reveal unequivocally the reasons . . .

     

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