HIGHLIGHTS
SUMMARY
Of laforin remain unclear, its functions in glycogen regulation, protecting cells from ER stress conditions, suppressing cytotoxicity production, autophagy regulation and tumor suppression have been proposed (Worby et_al, 2006; Garyali et_al, 2009; Vernia et_al, 2009; Gentry et_al, 2013). This evidence suggests that EPM2A gene_expression has diagnostic potential in early tumor detection, can reflect the progression trend and may become a novel therapeutic target. To define high-risk PCA, prostate-specific antigen (PSA), T, N, M classification and Gleason scores (GS) have been used to construct risk stratification schemes (Kattan et_al, 1998; D`Amico et_al . . .
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