Erα-lbd, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

HIGHLIGHTS

• who: Antonio Strillacci from the (UNIVERSITY) have published the research work: ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance, in the Journal: (JOURNAL)
• what: The authors investigated ERα protein and transcripts in ESR1 wild-type breast cancers that were resistant to fulvestrant and in TNBC. Across all the models the authors investigated, the authors found that fulvestrant increased expression of ERα-LBD and in some cases was necessary for detection. To further establish the functional significance of cytoplasmic and mitochondrial ERα-LBD, the authors performed co-IP and . . .
  

   

  

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