Er-stress and senescence coordinately promote endothelial barrier dysfunction in diabetes-induced atherosclerosis

HIGHLIGHTS

  • who: Sameen Fatima and colleagues from the Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital, Magdeburg, Germany have published the research: ER-Stress and Senescence Coordinately Promote Endothelial Barrier Dysfunction in Diabetes-Induced Atherosclerosis, in the Journal: Nutrients 2022, 14, x FOR PEER REVIEW verified of 27/05/2022
  • what: The aim of this study was to characterize the molecular alterations of a dysfunctional vascular endothelium in response to hyperglycaemic versus hyperlipidaemic conditions. The authors demonstrate that HG (as compared to oxLDL) induced pronounced maladaptive unfolded protein response (UPR) and senescence which . . .

     

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