Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo

HIGHLIGHTS

• who: Sajib Chakraborty from the Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany University of have published the article: Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo, in the Journal: (JOURNAL) of September/20,/2022
• what: By time-resolved transcriptomics and proteomics the authors show that Epo induces CFU-E cells a gradual transition from proliferation signature proteins to proteins indicative for differentiation including heme-synthesis enzymes. the absence of the Epo receptor (EpoR) embryos the authors observe a lack of hemoglobin CFU-E cells . . .
  

   

  

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